abstract：:The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...

journal_title：Hearing research

authors： Martini M,Rispoli G,Farinelli F,Fesce R,Rossi ML

更新日期：2004-09-01 00:00:00

abstract：:Cochlear function and susceptibility to noise over-exposure were examined in the congenic mouse strain B6.CAST+Ahl (B6.CAST) and compared to these same features in the CAST/Ei (CAST) and C57BL/6J (C57) parental strains. For both types of comparisons, the primary measure was the distortion-product otoacoustic emissions...

journal_title：Hearing research

authors： Vázquez AE,Jimenez AM,Martin GK,Luebke AE,Lonsbury-Martin BL

更新日期：2004-08-01 00:00:00

abstract：:During the simultaneous monaural presentation of two primary tones, distortion products can be measured acoustically in the ear canal (DPOAEs) and electrically as auditory evoked potentials (DPAEPs). The purpose of this investigation was to elucidate the sources of nonlinearity within the human auditory system respons...

journal_title：Hearing research

authors： Bhagat SP,Champlin CA

更新日期：2004-07-01 00:00:00

abstract：:Spectral analysis of electrical noise recorded from the round window (RW) of the cochlea is referred to as the ensemble spontaneous activity (ESA) of the cochlear nerve. The ESA is considered to represent the summed spontaneous activity of single fibers of the auditory nerve and changes in the spectral characteristics...

journal_title：Hearing research

authors： Searchfield GD,Muñoz DJ,Thorne PR

更新日期：2004-06-01 00:00:00

abstract：:The influence of temporal cues on sequential stream segregation was investigated using five elderly hearing-impaired listeners. In experiment 1, an alternating pattern of A and B tones was used. Each tone was a harmonic complex with a 100-Hz fundamental, with one of three passbands (1250-2500, 1768-3636, or 2500-5000 ...

journal_title：Hearing research

authors： Stainsby TH,Moore BC,Glasberg BR

更新日期：2004-06-01 00:00:00

abstract：:The effect of a preceding (adapter) sound on the spatial discrimination of two subsequent, successively presented (target) sounds was tested in the horizontal plane. The adapter and the first target were located in front of the subject or 30 degrees to the right of the midline; both sounds were presented either at the...

journal_title：Hearing research

authors： Getzmann S

更新日期：2004-05-01 00:00:00

abstract：:Carboplatin is currently being used as an anticancer drug against human cancers. However, high dose of carboplatin chemotherapy resulted in hearing loss in cancer patients. We have shown that carboplatin-induced hearing loss was related to dose-dependent oxidative injury to the cochlea in rat model. However, the time ...

journal_title：Hearing research

authors： Husain K,Scott B,Whitworth C,Rybak LP

更新日期：2004-05-01 00:00:00

abstract：:Tone-burst-evoked compound action potentials (CAP) from the guinea pig round window (RW) are altered by DC current injection through the RW. The CAP waveform consists of a series of interleaved negative and positive peaks (N(1), P(1), N(2), P(2) etc.) of decreasing amplitude. During positive DC current injection (arou...

journal_title：Hearing research

authors： Brown DJ,McMahon CM,Patuzzi RB

更新日期：2004-04-01 00:00:00

abstract：:It has previously been demonstrated that ototoxicity induced by systemic administration of cisplatin is reduced by concomitant systemic administration of alpha-melanocyte stimulating hormone (alpha-MSH). In this study we investigated the effects of cochlear, perilymphatic application of alpha-MSH during intraperitonea...

journal_title：Hearing research

authors： Wolters FL,Klis SF,Hamers FP,de Groot JC,Smoorenburg GF

更新日期：2004-03-01 00:00:00

abstract：:Adenosine plays a major cytoprotective role during ischemia and conditions of oxidative stress. Previous studies in our laboratory indicate that oxidative stress induces expression of the A1 adenosine receptor (A1AR) via activation of nuclear factor (NF)-kappaB. In this study, we tested whether noise exposure could in...

journal_title：Hearing research

authors： Ramkumar V,Whitworth CA,Pingle SC,Hughes LF,Rybak LP

更新日期：2004-02-01 00:00:00

abstract：:Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...

journal_title：Hearing research

authors： Whittemore KR Jr,Merchant SN,Poon BB,Rosowski JJ

更新日期：2004-01-01 00:00:00

abstract：:This study was performed to elucidate the contribution of the stapedial artery (SA)--which has been considered to be independent of the vertebrobasilar system--to blood flow in the ear by observing ear blood flow in Sprague-Dawley rats. A laser-Doppler (LD) probe was positioned on the bony wall of the cochlear basal t...

journal_title：Hearing research

authors： Yamamoto H,Tominaga M,Sone M,Nakashima T

更新日期：2003-12-01 00:00:00

abstract：:Light microscopy and immunohistochemical analyses of a freshly prepared human cochlea, removed at meningioma skull base surgery, were performed with particular emphasis on synaptophysin (SY) reactivity. Synaptophysin, a 38-kDa glycoprotein, is one of the most abundant integral membrane proteins of small presynaptic ve...

journal_title：Hearing research

authors： Khalifa SA,Friberg U,Illing RB,Rask-Andersen H

更新日期：2003-11-01 00:00:00

abstract：:Chromogranin A (CgA) belongs to the family of chromogranin peptides which are contained in large dense-core vesicles. The novel CgA fragment catestatin (bovine CgA(344-364); RSMRLSFRARGYGFRGPGLQL) is a potent inhibitor of catecholamine release by acting as a nicotinic cholinergic antagonist. Catestatin is a recently c...

journal_title：Hearing research

authors： Bitsche M,Mahata SK,Marksteiner J,Schrott-Fischer A

更新日期：2003-10-01 00:00:00

abstract：:The amplitude values of transient-evoked otoacoustic emissions, recorded from a large sample of neonates, were used to examine the asymmetry between ears tested and the differences due to the sex of the subject. Whilst the sex difference, with females having larger responses than males, has been a consistent finding i...

journal_title：Hearing research

authors： Thornton AR,Marotta N,Kennedy CR

更新日期：2003-10-01 00:00:00

abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...

journal_title：Hearing research

authors： Gross J,Rheinländer C,Fuchs J,Mazurek B,Machulik A,Andreeva N,Kietzmann T

更新日期：2003-09-01 00:00:00

abstract：:Cochlear serotonergic innervation is constituted by efferent fibers projecting both to the area below the inner and the outer hair cells. Previous detection of serotonin (5-HT) metabolites and 5-HT receptor mRNAs suggests the existence of serotonergic synaptic activity in the cochlea. The present study explores this p...

journal_title：Hearing research

authors： Vicente-Torres MA,Dávila D,Bartolomé MV,Carricondo F,Gil-Loyzaga P

更新日期：2003-08-01 00:00:00

abstract：:Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...

journal_title：Hearing research

authors： Moore BC,Moore GA

更新日期：2003-08-01 00:00:00

abstract：:The directional dependence of sound pressure transformation of head and pinna has been measured in the phyllostomid bat Phyllostomus discolor for the frontal hemisphere using a maximum length sequence method. The azimuthal position of the axis of highest pinna gain came closer to the midsagital plane with increasing f...

journal_title：Hearing research

authors： Firzlaff U,Schuller G

更新日期：2003-07-01 00:00:00

abstract：:The organisation and response properties of the rat auditory cortex were investigated with single and multi-unit electrophysiological recording. Two tonotopically organised 'core' fields, i.e. the primary (A1) and anterior (AAF) auditory fields, as well as three non-tonotopically organised 'belt' fields, i.e. the post...

journal_title：Hearing research

authors： Rutkowski RG,Miasnikov AA,Weinberger NM

更新日期：2003-07-01 00:00:00

abstract：:Increase in spontaneous neural activity after noise-induced hearing loss has frequently been associated with the phenomenon of tinnitus. Eighteen juvenile and adult cats were exposed for 2 h to a 6 kHz tone with an intensity of 115 dB SPL at the cat's head. Seven non-exposed littermates and seven other normal hearing ...

journal_title：Hearing research

authors： Seki S,Eggermont JJ

更新日期：2003-06-01 00:00:00

abstract：:This study introduces and evaluates a method for measurement of the longitudinal spread of electrically evoked neural excitation in the cochlea, using the Neural Response Telemetry system (NRT) available with the Nucleus((R)) 24 cochlear implant system. The recently released version of the NRT software (version 3.0) e...

journal_title：Hearing research

authors： Cohen LT,Richardson LM,Saunders E,Cowan RS

更新日期：2003-05-01 00:00:00

abstract：:We studied hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula both in untreated animals and at early and late time intervals following a single high dose of gentamicin. The study was carried out using the S-phase marker 5-bromo-2'-deoxyuridine. Our ultrastructural and immunofluorescence stud...

journal_title：Hearing research

authors： Avallone B,Porritiello M,Esposito D,Mutone R,Balsamo G,Marmo F

更新日期：2003-04-01 00:00:00

abstract：:Noise-induced hearing loss (NIHL) and hair cell loss are known to show only a moderate correlation. One reason for this is that NIHL may reflect not only the sum of dead hair cells, but also the sum of impaired but still living hair cells. This report compares hair cell loss in different cochlear regions in rats with ...

journal_title：Hearing research

authors： Chen GD,Fechter LD

更新日期：2003-03-01 00:00:00

abstract：:Gross electrical responses to tone bursts were measured in the guinea pig with electrodes located in scala tympani (ST) and scala vestibuli (SV) of the cochlea, on the central portion of the VIIIth nerve fibres in the internal auditory meatus, and on the surface of the cochlear nuclear complex (CN). Intracochlear perf...

journal_title：Hearing research

authors： Sellick P,Patuzzi R,Robertson D

更新日期：2003-02-01 00:00:00

abstract：:Tinnitus is most often initiated by modality specific otopathologic disturbances affecting peripheral and central auditory pathways. However, there is growing evidence indicating that the anatomical location generating tinnitus occurs at sites different from the initial pathology. Support for this notion is found in i...

journal_title：Hearing research

authors： Cacace AT

更新日期：2003-01-01 00:00:00

abstract：:The rather shallow growth of click-evoked otoacoustic emissions (CEOAE) with click intensity, namely <1 dB/dB, distinguishes genuine CEOAEs from stimulus artifacts, thereby providing the rationale for the popular 'derived nonlinear recording' method. However, other CEOAE nonlinearities regarding phase or envelope depe...

journal_title：Hearing research

authors： Carvalho S,Büki B,Bonfils P,Avan P

更新日期：2003-01-01 00:00:00

abstract：:The cochlear microphonic (CM) is produced by a change in standing currents during the motion of the cochlear partition. The motion of the partition and associated hair cell transduction processes are nonlinear and are reflected in the variation of the instantaneous frequency (IF) of the CM. Although the CM is dominate...

journal_title：Hearing research

authors： Chertoff ME,Amani-Taleshi D,Guo Y,Burkard R

更新日期：2002-12-01 00:00:00

abstract：:We have investigated the morphometric changes in the cochlear nucleus of patients who had undergone cochlear implantation following profound deafness. The brain stems of 11 adult patients who had undergone implantation and four non-implanted control cases with varying degrees of hearing loss were studied. The volumes ...

journal_title：Hearing research

authors： Chao TK,Burgess BJ,Eddington DK,Nadol JB Jr

更新日期：2002-12-01 00:00:00

abstract：:Blind cave fish employ superficial neuromasts to detect currents [Baker, C.F. and J.C. Montgomery, J. Comp. Physiol. A 184 (1999) 519-527]. Briefly exposing fish to calcium-free water significantly reduces the ability of the fish to perform rheotaxis (i.e., to orient properly in currents). Spontaneous recovery to cont...

journal_title：Hearing research

authors： Berg A,Watson GM

更新日期：2002-12-01 00:00:00

abstract：:The mechanisms underlying the ototoxicity of ethacrynic acid (EA) are not fully understood. Previous studies have focused on morphologic and enzymatic changes in the stria vascularis. The current experiment shows that one of the earliest effects of EA is ischemia, resulting from impaired blood flow in vessels supplyin...

journal_title：Hearing research

authors： Ding D,McFadden SL,Woo JM,Salvi RJ

更新日期：2002-11-01 00:00:00

abstract：:Activation of heat shock factors (Hsfs) is one of the potential mechanisms for regulating the transcription of the heat shock proteins (Hsps) and certain other stress-responsive genes. Reverse transcription polymerase chain reaction (RT-PCR), Western blot and immunocytochemistry were used to examine the expression and...

journal_title：Hearing research

authors： Fairfield DA,Kanicki AC,Lomax MI,Altschuler RA

更新日期：2002-11-01 00:00:00

abstract：:In this study, which aims to investigate for the first time auditoty sensitivity in congenital central hypothyroidism (CH), we concluded that: (1) permanent sensorineural hearing loss may be observed not only in congenital primary disorders of thyroid function, as reported hitherto; (2) it may also be found in patient...

journal_title：Hearing research

authors： Wasniewska M,De Luca F,Siclari S,Salzano G,Messina MF,Lombardo F,Valenzise M,Ruggeri C,Arrigo T

更新日期：2002-10-01 00:00:00

abstract：:The ultrastructure of the spiral ligament was compared in aged and young gerbils to assess the involvement of connective tissues in the lateral wall and particularly the fibrocytes in development of presbyacusis. Pathologic features in fibrocytes of senescent gerbils spanned a wide range reflecting different stages of...

journal_title：Hearing research

authors： Spicer SS,Schulte BA

更新日期：2002-10-01 00:00:00

abstract：:The inner ear contains receptor cells that oscillate spontaneously, generating waves that propagate backward in the cochlea, ultimately causing sound to be radiated into the ear canal--the spontaneous otoacoustic emissions (SOAEs). Except in rare conditions, these internally generated signals appear to go unheard. The...

journal_title：Hearing research

authors： Norena A,Micheyl C,Durrant J,Chéry-Croze S,Collet L

更新日期：2002-09-01 00:00:00

abstract：:Nitric oxide (NO) hyperpolarizes vascular smooth muscle cells and dilates blood vessels of various beds, but little is known on cochlear vasculatures. Using in vitro preparations of the spiral modiolar artery (SMA), intracellular electrical recording and labeling techniques, we found that the NO donor DPTA-NONOate (10...

journal_title：Hearing research

authors： Si JQ,Zhao H,Yang Y,Jiang ZG,Nuttall AL

更新日期：2002-09-01 00:00:00

abstract：:Both outer hair cells (OHCs) and inner hair cells (IHCs) survive and mature in 3 days old rat organ of Corti explants cultured for 1 month in a minimal essential medium. In contrast, under the same culture conditions, only IHCs survive in explants from adult guinea pig organ of Corti while many of the OHCs are lost wi...

journal_title：Hearing research

authors： Malgrange B,Rigo JM,Coucke P,Thiry M,Hans G,Nguyen L,van de Water TR,Moonen G,Lefebvre PP

更新日期：2002-08-01 00:00:00

abstract：:Applying whole-head functional magnetic resonance imaging (fMRI) in 11 neurologically intact subjects, hemodynamic responses to mon- or binaurally presented auditory stimuli were measured. To expand on previous studies in this research area, we used tones and consonant-vowel (CV) syllables. In one group of subjects (n...

journal_title：Hearing research

authors： Jäncke L,Wüstenberg T,Schulze K,Heinze HJ

更新日期：2002-08-01 00:00:00

abstract：:Immunolabeling of heregulin, a growth factor that enhances cell proliferation in damaged utricles, and one of its binding receptors, ErbB-2, has been briefly described in the P3 rat cochlea and utricle [Zheng et al. (1999) J. Neurocytol. 28, 901-912]. However, little is known about the distribution of heregulin and it...

journal_title：Hearing research

authors： Zhang M,Ding D,Salvi R

更新日期：2002-07-01 00:00:00

abstract：:This review is concerned with the operation of circuits in the central auditory system, how they transform response features and what functional significance may be attributed to those transformations. We focus on the role that GABAergic inhibition plays in processing interaural intensity disparities (IIDs), the princ...

journal_title：Hearing research

authors： Pollak GD,Burger RM,Park TJ,Klug A,Bauer EE

更新日期：2002-06-01 00:00:00